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The best choice for feeding an orphaned puppy is to use a commercial puppy milk replacer. This option is specifically formulated to provide the necessary nutrients that puppies need during their early development stages. These replacers are designed to mimic the composition of a mother dog's milk, ensuring that the orphaned puppy receives the optimal balance of proteins, fats, vitamins, and minerals essential for growth. While homemade milk mixtures may be a temporary alternative, they often lack the proper nutritional balance and can lead to deficiencies or health issues for the growing puppy. Regular cow's milk is not suitable for puppies, as it does not contain the right proportions of nutrients and can cause digestive upset due to lactose intolerance in many dogs. Thus, while other options might seem plausible, the best and safest choice is a commercial puppy milk replacer to ensure the health and well-being of the puppy.